MIC - 1 Stem Cells
Antlers are one of the fastest growing mammalian tissues, growing as much as two centimeters per day during peak antler growth.
The annual regeneration cycle, as well as the speed of it, are, in the world of biology, fenomenal, and cells taking part in this process have unparalleled, enormous, utterly unique regeneration potential. This knowledge has inspired us to conduct research to make it possible to use this fenomenon in the widely understood regenerative human and veterinary medicine, as well as in dermatology and cosmetology. An unlimited access to our own stem cell bank and an innovative industrial cell culture scale, offer great opportunities of the stem cells application, which may benefit potential patients as well as investors.
Fig. 1, 2. MIC-1 cell culture examination in a phase contrast microscope
The unique properties of stem cells, are, among other things, related to a natural production of over a dozen of growth factor proteins which induce regeneration processes. They stimulate the division and differentiation of other cells through a specific receptor mechanism. Natural composition of the growth factors constitutes a remarkable base for the regeneration of skin, soft tissues, bone growth, wound healing due to stimulation of collagen-producing fibroblasts and other matrix proteins. The growth factors increase activity of progenitor cells (the progenitor cells are in the „center” between stem cells about to differentiate into various tissues and fully differentiated cells which compose the target tissue.) We have used this knowledge for hair growth stimulation research and treatment of the corneal damage in animals. Skillful application and improvement of the mechanisms behind transformation of stem cells into hair follicle progenitor cells, may resolve the issue of a decrease in their activity and, subsequently, hold back the balding process.
Growth factors produced by MIC-1 cells
• Insulin-like growth factor I (IGF-1), II (IGF-2)
• Transforming growth factor (TGFα, TGFβ)
• Nerve growth factor (NGF)
• Fibroblast growth factor (FGF – 3 types)
• Granulocyte colony-stimulating factor (G-CSF)
• Granulocyte-macrophage colony-stimulating factor (GM-CSF)
• Hepatocyte growth factor (HGF)
• Epidermal growth factor (EGF)
Fig. 3. Ultrastructure of cells synthesizing large amounts of growth factors
Fig. 4. Expression of FGF2 protein in the cytoplasm of MIC-1 cells
Standard cell therapy uses living stem cells. Throughout the research, we have proved and confirmed the great potential of application of their homogenate. The homogenate is a mixture of naturally composed, fully active proteins and peptides derived after ultrasound separation of the cultured cells. Use of stem cells homogenate is a safe method and for the technical, logistical and economic reasons it is more efficient and much more cost-effective.
It is also possible to use lyophilizate and supernatant (post-culture liquid derived after the antlerogenic cells growth cycle, which contains threefold more protein, and, what follows, growth factors, as well).